Pharmacoeconomic Analysis Of Anidulafungin, Micafungin, Caspofungin And Fluconazole In The Treatment Of Candidemia And/Or Invasive Candidiasis In Non-Neutropenic Adult Patients In Spain.

• A decision tree model was performed (Figure 1). • The success (clinical and microbiological response) and safety (hepatic and renal adverse effects) of first-line treatments were obtained from meta-analyses and systematic reviews of clinical trials (Table 1). • In the case of failure, a second-line treatment (liposomal amphotericin B after the echinocandins, or one of the echinocandins after fluconazole) was administered. • The duration of the treatments (14 days total) was established by a panel of clinical experts using the Delphi method and according to IDSA guidelines (Table 1). • The cost of the medications and renal toxicity were considered (Table 1). • Deterministic and probabilistic sensitivity analysis using Monte Carlo simulations were carried out. METHODS